Related Experiment Video

Updated: Jul 8, 2026

Biochemical Measurement of Neonatal Hypoxia
13:13

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

Malarial anaemia in African children associated with high oxygen-radical production

B Greve, P G Kremsner, B Lell

    Lancet (London, England)
    |January 1, 2000
    PubMed

    Insights

    Children with severe malaria and anemia in Gabon show higher levels of reactive oxygen intermediates, which are implicated in both disease progression and parasite clearance.

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Malariology

    Background:

    • Reactive oxygen intermediates (ROIs) play a dual role in malaria pathogenesis, potentially contributing to illness while also aiding parasite destruction.
    • Understanding ROI involvement is crucial for developing effective malaria treatments.

    Purpose of the Study:

    • To investigate the innate production of reactive oxygen intermediates in Gabonese children experiencing severe malaria and concurrent anemia.
    • To correlate ROI levels with disease severity in this specific pediatric population.

    Main Methods:

    • Measurement of innate reactive oxygen intermediate production.
    • Analysis of clinical data from Gabonese children diagnosed with severe malaria and anemia.

    Main Results:

    • Significantly elevated levels of reactive oxygen intermediates were observed in children with severe malaria and anemia.
    • This finding suggests a heightened oxidative stress response in these patients.

    Conclusions:

    • Innate reactive oxygen intermediate production is increased in Gabonese children with severe malaria and anemia.
    • These findings contribute to understanding the complex pathophysiology of severe malaria and highlight the role of oxidative stress.

    More Related Videos

    Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice08:02

    Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

    Published on: October 19, 2013

    Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum10:22

    Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

    Published on: December 4, 2015

    Related Concept Videos

    Disorders of Erythrocytes01:27

    Disorders of Erythrocytes

    Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
    Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
    A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
    On the other...
    Factors Affecting Erythropoiesis01:24

    Factors Affecting Erythropoiesis

    The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
    Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
    EPO then...
    Oxygen Transport in the Blood01:27

    Oxygen Transport in the Blood

    Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
    Inborn Errors of Metabolism01:20

    Inborn Errors of Metabolism

    Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
    Malaria01:29

    Malaria

    Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
    Antiprotozoal Agents01:21

    Antiprotozoal Agents

    Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...