Related Experiment Video
Updated: Jul 26, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
A rare case of sarcoidosis with bilateral leg lymphedema as an initial symptom
1The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Abstract:
A 55-year-old man was admitted to our hospital because of bilateral leg lymphedema. He also showed subcutaneous nodules and CT scan disclosed multiple enlarged lymph nodes at thoracic, abdominal, and inguinal areas. Biopsy of the inguinal lymph node and the subcutaneous nodule revealed noncaseating epithelioid cell granuloma, a finding consistent with sarcoidosis. Lymphedema was attributed to the blockade of lymph flow by the systemic lymph node involvement of the disease. Within 1 week after the initiation of steroid therapy, his leg edema disappeared. Lymphedema could be the initial symptom of systemic sarcoidosis.
Related Concept Videos
Development of the Lymphatic System
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Nephrotic Syndrome I : Introduction
Multiple Sclerosis l: Introduction
Cirrhosis I: Introduction

