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Digoxin, hypercalcaemia, and cardiac conduction.

A Vella1, T C Gerber, D L Hayes

  • 1Department of Internal Medicine, Mayo Clinic & Foundation, Rochester, MN 55905, USA.

Postgraduate Medical Journal
|January 5, 2000
PubMed
Summary
This summary is machine-generated.

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Hypercalcaemia can cause cardiac arrhythmias, especially when combined with digoxin. Discontinuing digoxin and correcting high calcium levels resolved a patient's symptomatic arrhythmia.

Area of Science:

  • Cardiology
  • Oncology
  • Endocrinology

Background:

  • Hypercalcaemia typically shortens the QT-interval.
  • Clinically significant arrhythmias due to hypercalcaemia are rare.
  • Concomitant digoxin therapy or cardiac disease can increase arrhythmia risk.

Observation:

  • A patient with hypercalcaemia secondary to lung cancer developed a symptomatic arrhythmia.
  • The patient was concurrently receiving digoxin therapy.
  • The arrhythmia resolved upon digoxin withdrawal and correction of hypercalcaemia.

Findings:

  • Hypercalcaemia, particularly with digoxin, can precipitate symptomatic arrhythmias.
  • The case highlights the potentiating effect of digoxin on hypercalcaemia-induced cardiac events.

Related Experiment Videos

  • Successful management involved addressing both hypercalcaemia and digoxin exposure.

    • Implications:

    • Consider hypercalcaemia in unexplained bradyarrhythmias.
    • Discontinue digoxin in patients with hypercalcaemia.
    • Evaluate for rhythm disorders in hypercalcaemic patients undergoing treatment.