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Ciprofloxacin-induced bone marrow depression.

T K Dutta1, B A Badhe

  • 1Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Postgraduate Medical Journal
|January 5, 2000
PubMed
Summary
This summary is machine-generated.

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Ciprofloxacin, a fluoroquinolone antibiotic, can rarely cause life-threatening bone marrow failure. While one patient recovered after stopping the drug, another experienced fatal bleeding due to severe thrombocytopenia.

Area of Science:

  • Pharmacology
  • Hematology
  • Toxicology

Background:

  • Ciprofloxacin is a widely used, broad-spectrum fluoroquinolone antibiotic.
  • Generally regarded as safe, fluoroquinolones can occasionally lead to severe adverse events.

Observation:

  • Two cases of bone marrow failure associated with ciprofloxacin use are presented.
  • One case demonstrated reversible bone marrow suppression after drug discontinuation.
  • The second case involved irreversible bone marrow depression, resulting in fatal thrombocytopenia and hemorrhage.

Findings:

  • Ciprofloxacin can induce severe, potentially fatal, bone marrow failure.
  • The mechanism may involve an idiosyncratic reaction to the drug.
  • Bone marrow recovery is possible in some cases upon ciprofloxacin withdrawal.

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Implications:

  • Clinicians should be vigilant for hematological toxicity in patients receiving ciprofloxacin.
  • Awareness of this rare but serious complication is crucial for patient safety.
  • Further investigation into the idiosyncratic mechanisms of fluoroquinolone-induced bone marrow suppression is warranted.