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Site-specific formation of abasic lesions in DNA
1Department of Chemistry, Ohio State University, Columbus 43210-1185, USA.
Nucleosides & Nucleotides
|January 5, 2000
Abstract:
A method for the introduction of depurinated lesions in DNA is described, and is based on the formation of a covalent cross-link between an antisense oligonucleotide probe and the target DNA sequence followed by an unexpectedly mild thermal depurination.