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Synthesis and biological activity of modified thiopyrimidine nucleosides
A M Attia1, M A Sallam, A A Almehdi
1Department of Chemistry, Faculty of Education, Tanta University, Kafr El- Sheikh, Egypt.
Nucleosides & Nucleotides
|January 5, 2000
Abstract:
N3-beta-D-glucopyranosyl, galactopyranosyl and xylopyranosyl 6-methyl-2-methylthiouracil and their 5-bromo derivatives have been synthesized by coupling an alpha-acetobromosugar with the corresponding thiouracil. The new modified thiouridine analogues were evaluated for their inhibitory activity against Human Immunodeficiency Virus (HIV) replication in MT-4 cells as well as for their cytotoxicity.