Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Maximum-likelihood reconstruction with ordered subsets in bone SPECT.

D Blocklet¹, A Seret, N Popa

¹Hôpital Universitaire Erasme, Radioisotopes, Université Libre de Bruxelles, Brussels, Belgium.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine

|January 5, 2000

Summary

Ordered-subset expectation maximum (OSEM) reconstruction significantly improves bone single-photon emission computed tomography (SPECT) image quality over filtered backprojection (FBP). OSEM reduces artifacts and enhances visualization of bone lesions and activity, benefiting clinical practice.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Discrimination of dynamically and post-dynamically recrystallized grains based on EBSD data: application to Inconel 718.

Journal of microscopy·2018

Same author

Biodistribution and Radiation Dosimetry for the Novel SV2A Radiotracer [(18)F]UCB-H: First-in-Human Study.

Molecular imaging and biology·2015

Same author

Hybrid microPET imaging for dosimetric applications in mice: improvement of activity quantification in dynamic microPET imaging for accelerated dosimetry applied to 6-[18 F]fluoro-L-DOPA and 2-[18 F]fluoro-L-tyrosine.

Molecular imaging and biology·2013

Same author

Fallout radionuclide-based techniques for assessing the impact of soil conservation measures on erosion control and soil quality: an overview of the main lessons learnt under an FAO/IAEA Coordinated Research Project.

Journal of environmental radioactivity·2012

Same author

Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2011

Same author

[Economic evaluation of telehomecare in chronic lung diseases].

La Clinica terapeutica·2011

Area of Science:

Nuclear Medicine
Medical Imaging
Radiology

Background:

Filtered backprojection (FBP) is a standard reconstruction algorithm for bone SPECT.
Artifacts and limitations in image quality can impact diagnostic accuracy with FBP.

Purpose of the Study:

To compare the effectiveness of ordered-subset expectation maximum (OSEM) versus FBP for bone SPECT in routine clinical settings.
To evaluate the impact of OSEM on image quality, artifact reduction, and lesion detection.

Main Methods:

Analysis of 57 bone SPECT studies across various anatomical regions.
Acquisition using single-head cameras with 64 projections over 360 degrees.
Comparison of OSEM and FBP reconstructed images by three independent observers.

Related Experiment Videos

Main Results:

OSEM rarely generated streak artifacts compared to FBP.
OSEM improved visualization of hyperactive and low-activity regions, with 98% of images rated superior or equal to FBP.
Anatomical resolution and lesion definition were superior or equal with OSEM in 96% of cases.

Conclusions:

OSEM reconstruction offers significant advantages over FBP for bone SPECT.
Replacing FBP with OSEM is recommended to enhance clinical practice and diagnostic confidence.