Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Distinct prefrontal activations in processing sequence at the sentence and script level: an fMRI study.

S Crozier1, A Sirigu, S Lehéricy

  • 1INSERM U289, Hôpital de la Salpêtrière, Paris, France.

Neuropsychologia
|January 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tumor-stroma proportion on primary tumor as a prognostic biomarker in advanced ovarian cancer patients receiving chemo-immunotherapy as first-line therapy: analyses from the NeoPembrOV/GINECO phase II randomized trial.

ESMO open·2025
Same author

Diagnostic and prognostic yields of ambulatory blood pressure measurements in haemodialysis patients: a 6-year longitudinal study.

Acta cardiologica·2024
Same author

The pattern of cortical thickness associated with executive dysfunction in MCI and SCC: The MEMENTO cohort.

Revue neurologique·2024
Same author

"Time Saved" Calculations to Improve Decision-Making in Progressive Disease Studies.

The journal of prevention of Alzheimer's disease·2024
Same author

Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU): Trial Satisfaction and Attitudes towards Future Clinical Trials.

The journal of prevention of Alzheimer's disease..·2024
Same author

T1w/FLAIR ratio standardization as a myelin marker in MS patients.

NeuroImage. Clinical·2022
Same journal

Prevalence and modulation of rat off-track head scanning on linear tracks: possible implications for representational and dynamic properties of hippocampal place cells.

Neuropsychologia·2026
Same journal

Identifying networks within an fMRI multivariate searchlight analysis.

Neuropsychologia·2026
Same journal

Modulating sentence comprehension in people with aphasia through anodal tDCS: A double-blind randomized cross-over study.

Neuropsychologia·2026
Same journal

Deficient processing of regularity violations during visuospatial neglect: a visual mismatch negativity study.

Neuropsychologia·2026
Same journal

Seeing is believing: mental imagery amplifies moral, emotional, and motivational responding to mentally constructed hypothetical events.

Neuropsychologia·2026
Same journal

From past recall to future projection: What does verb tense production reveal about mental time travel in Alzheimer's disease?

Neuropsychologia·2026
See all related articles

This study reveals that specific prefrontal cortex regions are crucial for analyzing sequential actions. The dorsolateral prefrontal cortex and related areas are key to understanding action sequences.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Neuropsychological research highlights the prefrontal cortex's role in behavioral planning and monitoring.
  • Understanding the specific neural mechanisms underlying sequential action processing is an ongoing area of research.

Purpose of the Study:

  • To investigate the involvement of specific prefrontal cortex regions in processing sequences of actions.
  • To differentiate neural activation patterns between processing action sequences (scripts) and linguistic sequences (sentences).

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed to monitor brain activity.
  • Participants performed two tasks: Script-event order and Sentence-word order.
  • Analysis focused on identifying activated brain regions during each task.

Related Experiment Videos

Main Results:

  • Both Script-event order and Sentence-word order tasks activated overlapping brain areas associated with language processing.
  • The Script-task uniquely engaged significant portions of the dorsolateral prefrontal cortex (Brodmann areas 6 and 8) bilaterally.
  • Additional activation for the Script-task was observed in the left supplementary motor area and left angular gyrus (Brodmann area 39).

Conclusions:

  • Specific prefrontal cortex regions, particularly the dorsolateral prefrontal cortex, are critically involved in analyzing sequential links within the domain of actions.
  • These findings extend our understanding of prefrontal cortex function beyond general planning to include the specific analysis of action sequences.