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[Sarcoid optic neuropathy].

C Brindeau1, A Glacet-Bernard, B Roualdes

  • 1Clinique Ophtalmologique Universitaire, Centre Hospitalier Intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil.

Journal Francais D'Ophtalmologie
|January 5, 2000
PubMed
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Sarcoid optic neuropathy, a rare neurosarcoidosis complication, can cause vision loss. Prompt corticosteroid treatment is crucial for symptom resolution and preventing further neurological damage.

Area of Science:

  • Ophthalmology
  • Neurology
  • Pulmonology

Background:

  • Sarcoidosis is a multisystem granulomatous disease often affecting the chest.
  • Sarcoid optic neuropathy is an uncommon yet severe manifestation requiring prolonged corticosteroid therapy.

Observation:

  • A 50-year-old patient presented with blurred vision, diagnosed with retrobulbar optic neuropathy via visual field testing and evoked potentials.
  • Ophthalmologic examination was initially normal, but subsequent MRI revealed orbital masses and meningeal lesions suggestive of neurosarcoidosis.

Findings:

  • Diagnosis of sarcoidosis was presumed via imaging and confirmed by transbronchial biopsy showing non-caseating granulomas.
  • Intravenous corticosteroids initially resolved symptoms; however, relapse occurred, necessitating long-term high-dose corticosteroid therapy for neurosarcoidosis.

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Implications:

  • Optic neuropathy is a rare neurosarcoidosis presentation, often involving optic disc lesions.
  • Histopathological confirmation via biopsy is essential for diagnosing sarcoidosis.
  • Corticosteroid therapy is highly effective but may require extended treatment durations for neurosarcoidosis.