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Related Experiment Videos

Mitochondrial redox state in the critically ill.

K A Yassen1, H F Galley, A Lee

  • 1Department of Anaesthesia, Royal Infirmary, Edinburgh, UK.

British Journal of Anaesthesia
|January 5, 2000
PubMed
Summary

Arterial ketone body ratio (AKBR) monitoring may help manage critically ill patients. Serial AKBR measurements showed distinct trends in survivors versus non-survivors, indicating its potential as a prognostic marker.

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Area of Science:

  • Biochemistry
  • Critical Care Medicine
  • Mitochondrial Physiology

Background:

  • Critically ill patients often exhibit impaired mitochondrial function, leading to abnormal oxygen utilization and organ failure.
  • Mitochondrial dysfunction is a key factor in the pathophysiology of critical illness and sepsis.
  • The arterial ketone body ratio (AKBR) is a potential indicator of the mitochondrial redox state.

Purpose of the Study:

  • To investigate the utility of serial arterial ketone body ratio (AKBR) measurements in critically ill patients.
  • To determine if AKBR can serve as a marker for monitoring mitochondrial function and predicting outcomes.
  • To assess the relationship between AKBR trends and patient survival.

Main Methods:

  • Measurement of arterial ketone body ratio (acetoacetate to beta-hydroxybutyrate) and plasma lactate concentrations.

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  • Serial measurements were taken over 3 consecutive days in 20 critically ill patients.
  • Patient outcomes, including 30-day mortality, were recorded.

    • Main Results:

    • AKBR significantly increased over the study period in patients who died (P = 0.034).
    • AKBR significantly decreased in patients who survived (P < 0.0001).
    • A significant difference in AKBR trends was observed between survivors and non-survivors (P = 0.015).

    Conclusions:

    • Serial AKBR measurements may be a valuable tool for monitoring mitochondrial function in critically ill patients.
    • AKBR trends show potential as a prognostic marker, differentiating between survivors and non-survivors.
    • The findings suggest AKBR measurement could aid in the management of septic patients.