Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dementia with Lewy bodies.

I McKeith1, J O'Brien

  • 1Newcastle General Hospital, Newcastle upon Tyne, United Kingdom.

The Australian and New Zealand Journal of Psychiatry
|January 5, 2000
PubMed
Summary

Dementia with Lewy bodies (DLB) is a common degenerative dementia. Early recognition is crucial due to severe antipsychotic risks and distinct clinical features like fluctuating cognition, parkinsonism, and visual hallucinations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

I do what I want, which depends on what you do to help me understand what is at stake-my future.

Spine deformity·2026
Same author

Navigating Parenthood during Medical Training.

Irish medical journal·2026
Same author

The Prevalence of Burnout in Healthcare Workers Presenting to Occupational Health.

Irish medical journal·2025
Same author

Temporarily Externalisation of intra-thecal morphine pump to prevent opioid withdrawal.

Irish medical journal·2024
Same author

VasCog 2023: 20 years of research on vascular behavioural and cognitive disorders.

Cerebral circulation - cognition and behavior·2024
Same author

Long-term results of ablation index guided atrial fibrillation ablation: insights after 5+ years of follow-up from the MPH AF Ablation Registry.

Frontiers in cardiovascular medicine·2024

Area of Science:

  • Neurology
  • Geriatrics
  • Neuroscience

Background:

  • Dementia with Lewy bodies (DLB) is the second most frequent form of degenerative dementia in the elderly, representing up to 20% of cases.
  • DLB is characterized by a distinct triad: fluctuating cognitive impairment, spontaneous parkinsonism, and recurrent visual hallucinations.

Purpose of the Study:

  • To summarize recent clinical and research findings on dementia with Lewy bodies (DLB).
  • To highlight the clinical importance of recognizing DLB for patient safety and treatment.

Main Methods:

  • A comprehensive literature review using Medline.
  • Inclusion of data from recent DLB symposia and relevant publications known to the authors.

Main Results:

  • Consensus clinical and neuropathological criteria for DLB have been established, demonstrating high specificity.
  • DLB patients exhibit a high incidence (60%) of adverse reactions to antipsychotics, necessitating caution.
  • Neuroimaging shows potential for differentiating DLB from Alzheimer's disease (AD), including preserved temporal lobe structures and dopaminergic marker loss.

Conclusions:

  • Dementia with Lewy bodies is a distinct clinical and neuropathological entity, separate from Alzheimer's disease.
  • Clinicians must be aware of the characteristic triad of DLB symptoms to guide treatment and avoid dangerous antipsychotic use.
  • Ongoing research promises advancements in DLB diagnostics and therapeutics.

Related Experiment Videos