Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Occupational allergic alveolitis.

L C Grammer1

  • 1Division of Allergy Immunology, Bazley Center for Asthma and Allergic Diseases, Northwestern University Medical School, Chicago, Illinois 60611, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|January 5, 2000
PubMed
Summary

Hypersensitivity pneumonitis is a lung disease caused by occupational exposures. Reducing exposure to known antigens is key to preventing irreversible lung damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2018
Same author

Chronic airway inflammation provides a unique environment for B cell activation and antibody production.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2016
Same author

Elevated presence of myeloid dendritic cells in nasal polyps of patients with chronic rhinosinusitis.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2014
Same author

Reduced expression of antimicrobial PLUNC proteins in nasal polyp tissues of patients with chronic rhinosinusitis.

Allergy·2012
Same author

Acute hepatitis and rash to fluconazole.

Allergy·2003
Same author

Hypersensitivity to IFN-alpha.

Allergy·2001

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Occupational Health

Background:

  • Hypersensitivity pneumonitis (HP) is a significant occupational lung disease.
  • Various foreign proteins and chemicals act as causative agents.
  • The disease presents with acute, subacute, or chronic forms.

Purpose of the Study:

  • To review the immunopathogenesis and clinical presentation of hypersensitivity pneumonitis.
  • To highlight the role of antigen exposure in disease development and prevention.

Main Methods:

  • Review of existing literature on hypersensitivity pneumonitis.
  • Analysis of immunopathogenic mechanisms involving immune cells.
  • Correlation of clinical manifestations with exposure levels.

Main Results:

  • Antigens like proteins and chemicals trigger HP.
  • Activated CD8+ cells and macrophages are key in its immunopathogenesis.
  • Disease severity (acute, subacute, chronic) depends on exposure.

Conclusions:

  • Understanding HP's immunopathogenesis is crucial.
  • Minimizing exposure to identified antigens is a promising preventive strategy.
  • Early intervention can prevent irreversible lung disease.

Related Experiment Videos