Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Esophagectomy after induction chemoradiation.

M M DeCamp1, S J Swanson, M T Jaklitsch

  • 1Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, OH 44195, USA.

Chest
|January 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The rates of second lung cancers and the survival of surgically-resected second primary lung cancers in patients undergoing resection of an initial primary lung cancer.

Lung cancer (Amsterdam, Netherlands)·2020
Same author

Perspectives on surgical oncology in Africa.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2019
Same author

Rice root curling, a response to mechanosensing, is modulated by the rice E3-ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 (OsHOS1).

Plant signaling & behavior·2016
Same author

Should we continue to drain the pylorus in patients undergoing an esophagectomy?

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2013
Same author

Extent of lymph node resection does not increase perioperative morbidity and mortality after surgery for stage I lung cancer in the elderly.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2012
Same author

Confirmation of the role of diabetes in the local recurrence of surgically resected non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands)·2011

Standard therapy for resectable esophageal cancer is debated. Neoadjuvant chemoradiation shows promise for improving outcomes and is safe before surgery, guiding future treatment modifications.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • The optimal treatment for resectable esophageal cancer is controversial.
  • Previous preoperative therapies (radiotherapy, chemotherapy) showed feasibility but not improved survival.
  • Distant metastases remain a significant challenge in esophageal cancer management.

Purpose of the Study:

  • To review evidence on neoadjuvant therapy for resectable esophageal cancer.
  • To assess the safety and efficacy of induction therapy followed by esophagectomy.
  • To inform the development of evolving standards of care for this disease.

Main Methods:

  • Review of existing literature on preoperative treatments for esophageal cancer.
  • Analysis of data regarding neoadjuvant chemoradiation outcomes.

Related Experiment Videos

  • Evaluation of surgical outcomes following induction therapy.

    • Main Results:

    • Preoperative radiotherapy and chemotherapy are feasible but do not improve survival.
    • Concurrent neoadjuvant chemoradiation demonstrates encouraging pathologic responses.
    • Aggressive neoadjuvant therapies have not been associated with worse surgical outcomes.

    Conclusions:

    • Neoadjuvant chemoradiation is a feasible and potentially effective strategy for resectable esophageal cancer.
    • Induction therapy followed by esophagectomy appears safe and feasible.
    • Evidence supports a rational approach to modifying standards of care in esophageal cancer treatment.