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Related Experiment Videos

Microvessel density in prostatic hyperplasia.

S J Foley1, D M Bailey

  • 1Department of Urology, Royal Bournemouth Hospital, UK.

BJU International
|January 5, 2000
PubMed
Summary
This summary is machine-generated.

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Patients with benign prostatic hyperplasia (BPH) and hematuria show significantly higher microvessel density (MVD) in the prostate compared to controls. This suggests increased blood vessel growth contributes to hematuria in BPH.

Area of Science:

  • Urology
  • Pathology
  • Angiogenesis

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • Hematuria is a potential complication of BPH, impacting quality of life.
  • The underlying microvascular changes contributing to BPH-associated hematuria are not fully understood.

Purpose of the Study:

  • To investigate the microvascular anatomy of prostates in patients with BPH and hematuria.
  • To compare the microvessel density (MVD) between BPH patients with and without hematuria.
  • To identify histopathological differences at the cellular level.

Main Methods:

  • Prospective study comparing 11 BPH patients with hematuria and 19 BPH control patients.
  • Immuno-histochemistry (Factor VIII/CD-34) used to examine the sub-urothelial compartment.

Related Experiment Videos

  • Microvessel density (MVD) quantified by counting vascular cross-sectional profiles.

    • Main Results:

    • Median MVD was significantly higher in the hematuria group (64) compared to the control group (27) (P < 0.001).
    • This difference was observed in the sub-urothelial microvasculature.
    • Pathologist was blinded to patient clinical status.

    Conclusions:

    • Significantly greater MVD in BPH patients with hematuria suggests microvessel proliferation.
    • Suburothelial microvessel proliferation may be a key factor in mediating hematuria in BPH.
    • This study provides the first cellular-level evidence of differences in patients with BPH-related hematuria.