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Performance modeling and simulation of biochemical process sequences with interacting unit operations.

M E Groep1, M E Gregory, L S Kershenbaum

  • 1Centre for Process Systems Engineering, Imperial College, London SW7 2BY.

Biotechnology and Bioengineering
|January 5, 2000
PubMed
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Optimizing biochemical processes requires considering interactions between operations. A global objective yields better results than optimizing each step individually, improving overall process performance and economic benefits.

Area of Science:

  • Biochemical Engineering
  • Process Optimization
  • Industrial Biotechnology

Background:

  • Biochemical processes involve sequential operations requiring optimal setpoints.
  • Individual optimization of unit operations often leads to suboptimal overall performance.
  • Interactions between unit operations are critical for achieving global efficiency.

Purpose of the Study:

  • To demonstrate a method for formulating and solving optimization problems for entire biochemical processes.
  • To highlight the importance of considering inter-operation effects in process optimization.
  • To determine optimal operating conditions based on a global process objective.

Main Methods:

  • Development of a demonstrative model for a sequence of unit operations, including interaction effects.

Related Experiment Videos

  • Formulation of a global optimization problem for the entire process.
  • Comparison of results from global optimization versus individual operation optimization.

    • Main Results:

    • Optimal operating conditions determined by global optimization differ significantly from those of individual optimization.
    • Accounting for interaction effects is crucial for accurate process modeling.
    • The proposed strategy can lead to substantial economic benefits.

    Conclusions:

    • Global process optimization, considering inter-operation interactions, is superior to sequential individual optimization.
    • Further research into interaction modeling and performance optimization is warranted.
    • This approach offers a pathway to enhanced economic benefits in biochemical manufacturing.