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Related Experiment Videos

Nicotine microaerosol inhaler.

P G Andrus1, R Rhem, J Rosenfeld

  • 1Aerosol Research Laboratory, McMaster University, Hamilton, Canada. andrusp@fhs.csu.McMaster.CA

Canadian Respiratory Journal
|January 7, 2000
PubMed
Summary

This study measured nicotine inhaler droplet size, finding it mimics tobacco smoke delivery. This nicotine inhaler offers a safer alternative to smoking by avoiding combustion products.

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Area of Science:

  • Pharmaceutical Sciences
  • Aerosol Science

Background:

  • Metered-dose inhalers (MDIs) are used for drug delivery.
  • Nicotine delivery via inhalation is an area of interest for smoking cessation and harm reduction.

Purpose of the Study:

  • To characterize the droplet size distribution of a nicotine pressurized metered-dose inhaler.
  • To evaluate the potential of this MDI for mimicking nicotine delivery from tobacco smoke.

Main Methods:

  • Droplet size distribution was measured using a multistage liquid impinger (MLI) and a quartz crystal microbalance (QCM) impactor.
  • Nicotine in ethanol solution with hydrofluoroalkane propellant was used in the MDI formulation.

Main Results:

  • The mass median aerodynamic diameter (MMAD) was determined to be 1.6 µm by MLI and 1.5 µm by QCM impactor.
  • These droplet sizes indicate the formation of a fine aerosol.

Conclusions:

  • The tested nicotine MDI formulation produces a microaerosol with a fine droplet size.
  • This formulation can mimic the pulmonary nicotine delivery of tobacco smoke.
  • Nicotine delivery via this MDI is potentially safer than smoking due to the absence of combustion products.

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