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[Microbiological and clinical studies with Streptococcus pneumoniae isolated in 5 Kitakyushu municipal hospitals]
M Ishida1, H Watanabe, M Nagata
1Clinical Laboratory, Kitakyushu Municipal Hospital.
Abstract:
Epidemiological and microbiological studies were carried out using 200 strains of pneumococci isolated from clinical specimens in 5 Kitakyushu municipal hospitals, between October 1994 and July 1995. Eighty nine percent of pneumococci were detected in the specimens from the respiratory tract. Pneumococci were isolated mainly from infants under 3-years of age and adults over 50-years of age, and the rates of isolation were 40.5% and 39.5%, respectively. MICs of 8 antimicrobial agents, such as PCG, NFLX, CPFX, LFLX, FLRX, TFLX, SPFX, LVFX, were determined using broth microdilution methods. According to NCCLS standard (1997), recovery rates of PSSP, PISP and PRSP were 48.0%, 39.5% and 12.5%, respectively. Among 7 quinolones, TFLX, SPFX and LVFX were effective so far examined, except for a few resistant strains. Four cases in which quinolones resistant pneumococci were isolated were reviewed retrospectively. Among them 3 cases had been given quinolones before the strains were detected.
Insights
This study analyzed 200 pneumococci strains, finding respiratory tract infections common in infants and older adults. Fluoroquinolones like levofloxacin showed effectiveness against most strains, but resistance warrants monitoring.
Area of Science:
- Microbiology
- Epidemiology
- Infectious Diseases
Context:
- Pneumococcal infections pose a significant public health challenge, particularly in vulnerable populations.
- Antimicrobial resistance in Streptococcus pneumoniae necessitates ongoing surveillance and evaluation of treatment efficacy.
Purpose:
- To conduct epidemiological and microbiological analysis of pneumococci strains from clinical specimens.
- To determine the antimicrobial susceptibility patterns of isolated pneumococci strains to various agents, including fluoroquinolones.
- To investigate cases of fluoroquinolone-resistant pneumococci and identify potential risk factors.
Summary:
- A study of 200 pneumococci strains isolated from Kitakyushu municipal hospitals (Oct 1994-Jul 1995) revealed high prevalence in respiratory tract specimens.
- Pneumococci were predominantly isolated from infants (<3 years) and adults (>50 years).
- Penicillin-susceptible (PSSP), intermediate (PISP), and resistant (PRSP) rates were 48.0%, 39.5%, and 12.5% respectively. Fluoroquinolones (TFLX, SPFX, LVFX) demonstrated effectiveness against most strains, with resistance noted in a few.
- Retrospective review of four cases with fluoroquinolone-resistant pneumococci identified prior fluoroquinolone use in three patients.
Impact:
- Provides crucial data on pneumococcal epidemiology and antimicrobial resistance patterns in Japan.
- Highlights the effectiveness of certain fluoroquinolones against pneumococci while underscoring the emergence of resistance.
- Informs clinical decision-making and public health strategies for managing pneumococcal infections and antimicrobial stewardship.