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Related Experiment Videos

Severe pulmonary hypertensive diseases: a perspective.

N F Voelkel1, R M Tuder

  • 1Dept of Pathology, Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver 80262, USA.

The European Respiratory Journal
|January 7, 2000
PubMed
Summary

Severe pulmonary hypertension nomenclature is confusing. This perspective challenges the traditional classification and proposes a new association-morphology-function context for pulmonary hypertensive disorders.

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Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Pathology

Background:

  • The current nomenclature for severe pulmonary hypertension is confusing, with interchangeable use of terms like primary, idiopathic, unexplained, and plexogenic.
  • Traditional pathohistological classifications, such as that by Heath and Edwards, are being challenged.

Purpose of the Study:

  • To challenge the validity of the traditional pathohistological classification of severe pulmonary hypertension.
  • To propose a new classification system focused on histological and clinical associations.
  • To stimulate discussion for revising the nomenclature and classification of pulmonary hypertensive disorders.

Main Methods:

  • This is a perspective piece, not an experimental study.
  • It involves a critical review of existing classification systems.

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  • Proposes a new framework based on association, morphology, and function.

    • Main Results:

    • The traditional classification by Heath and Edwards is questioned.
    • A new classification approach integrating association, morphology, and function is suggested.
    • The authors advocate for a reordering of severe pulmonary hypertension categorization.

    Conclusions:

    • The current nomenclature and classification of severe pulmonary hypertension require revision.
    • An association-morphology-function context offers a more clinically relevant framework.
    • The proposed perspective aims to initiate a necessary change in the field.