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Apolipoprotein E polymorphisms and Parkinson's disease.

R L Oliveri1, G Nicoletti, R Cittadella

  • 1Institute of Neurology, Department of Medical Sciences, University of Catanzaro, Italy.

Neuroscience Letters
|January 7, 2000
PubMed
Summary
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This study found no association between apolipoprotein E (APOE) gene polymorphisms and Parkinson's disease (PD) risk or age at onset. Neither the APOE gene nor the -491 A/T polymorphism influenced PD development in the studied population.

Area of Science:

  • Genetics
  • Neurodegenerative Diseases
  • Molecular Biology

Background:

  • The apolipoprotein E (APOE) gene is implicated in various neurological disorders.
  • Conflicting results exist regarding the association between APOE gene polymorphisms and Parkinson's disease (PD).
  • A novel functional polymorphism (-491 A/T) in the APOE gene's regulatory region has been linked to Alzheimer's disease.

Purpose of the Study:

  • To investigate the association between two APOE gene polymorphisms (APOE and -491 A/T) and Parkinson's disease.
  • To determine if these polymorphisms affect the age of onset in PD patients.

Main Methods:

  • Genotyping of 126 Parkinson's disease patients and 119 controls.
  • Analysis of allelic and genotypic frequencies for APOE and -491 A/T polymorphisms.

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  • Comparison of genotype distributions and age at onset between PD cases and controls.

    • Main Results:

    • No significant differences in allelic or genotypic frequencies were observed for either the APOE or -491 A/T polymorphism between PD patients and controls.
    • The specific genotypes of the studied APOE polymorphisms did not correlate with the age at onset of Parkinson's disease.

    Conclusions:

    • The studied APOE gene polymorphisms, including -491 A/T, are not associated with an increased risk of developing Parkinson's disease.
    • These APOE variants do not appear to influence the age at which Parkinson's disease manifests.