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Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels
K Hogan1, R G Greg, P A Powers
1Department of Anesthesiology, University of Wisconsin, Madison 53792, USA. khogan@facstaff.wisc.edu
Neuroscience Letters
|January 7, 2000
Abstract:
The structure of the gene encoding the human brain beta1 subunit of voltage dependent calcium channels (CACNB1) was determined by comparison of its genomic sequence with beta1 cDNA sequence. CACNB1 is distributed over 25 kb and contains 13 exons. Alternative splicing of CACNB1 RNA occurs within the central domain at exon 7, and the 3' domain at exon 13, producing the variably expressed beta1a, beta1b and beta1c isoforms. Exon/intron boundaries and exon lengths are conserved for the nine exons shared by the beta1 and related brain beta3 and beta4 genes.