Inhibition of chemical carcinogenesis by Psoralea corylifolia seeds
Related Experiment Video
Updated: Aug 12, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
1Ethnomedicine and Ethnopharmacology Division, Tropical Botanic Garden and Research Institute, Kerala, India.
Abstract:
Psoralea corylifolia L. (Fabaceae) seeds are extensively used in Ayurvedic medicine. Topical application of 100 mg/kg body weight of the active fraction (AF) of P. corylifolia seeds inhibited the growth and delayed the onset of papilloma formation in mice, initiated with 7,12-dimethyl benz(a) anthracene and promoted using croton oil. The AF at the same dose, when administered orally, inhibited the growth of subcutaneously injected 20-methylcholanthrene (MCA)--induced soft tissue fibrosarcomas significantly. The AF has been shown by gas chromatography analysis to be composed of a mixture of glycerides of fatty acids.
More Related Videos
04:12Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
11:13Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
Published on: June 9, 2023
Related Concept Videos
Cancer Prevention
Some...
Mutagenicity and Carcinogenicity