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Localized bullous pemphigoid in a patient with B-cell lymphoma
C A Egan1, S R Florell, J J Zone
1Department of Dermatology, University of Utah School of Medicine, Section of Dermatology, Salt Lake City Veterans Affairs Medical Center, USA.
Abstract:
Bullous pemphigoid (BP) is an immunobullous disease characterized by circulating IgG antibodies directed towards cutaneous basement zone antigens. We report the case of a patient who had BP localized to a stoma site. At initial examination, a nodule was noted on the temple, which proved to be a large cell lymphoma, B-cell phenotype. On Western immunoblot, the patient's serum showed circulating IgG antibodies reactive with the 230 kDa BP antigen and the 97 kDa linear IgA bullous dermatosis antigen. The co-incident onset of the two diseases suggest that this may represent a case of paraneoplastic BP.
