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Does a relationship exist between the urate pool in the body and lipid peroxidation during exercise?
1Department of Health and Sports Science, Nippon Medical School, Kawasaki, Kanagawa, Japan. mikami@nms.ac.jp
Free Radical Research
|January 7, 2000
Summary
Urate levels before exercise influence lipid peroxidation. Higher urate levels correlate with better antioxidant capacity, suggesting urate acts as a key free-radical scavenger during physical exertion.
Area of Science:
- Exercise physiology
- Biochemistry
- Oxidative stress research
Background:
- Lipid peroxidation is a marker of oxidative stress during exercise.
- The role of urate as an in vivo antioxidant during physical exertion requires further investigation.
Purpose of the Study:
- To determine the relationship between pre-exercise urate levels and lipid peroxidation during exhaustive exercise.
- To evaluate the impact of manipulating urate levels on antioxidant capacity and oxidative stress markers.
Main Methods:
- Seven healthy males underwent exhaustive cycling under three conditions: benzbromarone (uricosuric), IMP (urate precursor), and control.
- Plasma and urine levels of urate, thiobarbituric acid reactive substances (TBARS), and allantoin were measured.
- Antioxidant capacity was assessed using the total peroxyl radical-trapping antioxidant parameter (TRAP).
Main Results:
- Plasma urate and TRAP levels decreased in the order IMP > control > benzbromarone.
- A positive correlation was found between plasma urate and TRAP values.
- Urinary TBARS excretion during recovery was negatively correlated with resting plasma urate levels.
Conclusions:
- Pre-exercise urate levels are a significant factor in modulating lipid peroxidation during exhaustive exercise.
- Urate demonstrates potential as a crucial in vivo free-radical scavenger, protecting against exercise-induced oxidative damage.