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Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

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Published on: November 21, 2014

A clonal view of alphabeta T cell responses

P Bousso1, P Kourilsky

  • 1Unité de Biologie Moléculaire du Gène, INSERM U277, Institut Pasteur, 25 rue du Dr Roux, Paris, Cedex 15, 75015-75724, France. bousso@pasteur.fr

Seminars in Immunology
|January 8, 2000
PubMed

Quantitative analyses of antigen (Ag)-specific alphabeta T cell populations have provided a large body of information on the natural course of T cell immune responses. New tools are now available to determine the clonal composition of Ag-specific pools in individual responders, an approach which offers direct insights into the generation of T cell immune responses and establishment of protective immunity. The present review discusses the parameters that determine the composition of Ag-specific T cell responses. Emphasis is placed on the role of the naive alphabeta T cell repertoire and on the dynamics of individual Ag-specific T cell clones during the successive phases of an immune response.

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