Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelin regulation of adrenal function.

C Hinojosa-Laborde1, D L Lange

  • 1Department of Physiology, University of Texas Health Science Center, San Antonio 78284, USA. laborde@uthscsa.edu

Clinical and Experimental Pharmacology & Physiology
|January 8, 2000
PubMed
Summary

Endothelin (ET) significantly influences the sympathetic nervous system by regulating adrenal medulla function. This peptide directly stimulates catecholamine release from adrenal chromaffin cells, impacting sympathetic responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

gamma-Aminobutyric acid (GABA)--A function and binding in the paraventricular nucleus of the hypothalamus in chronic renal-wrap hypertension.

Hypertension (Dallas, Tex. : 1979)·2001
Same author

Endothelin enhances and inhibits adrenal catecholamine release in deoxycorticosterone acetate-salt hypertensive rats.

Hypertension (Dallas, Tex. : 1979)·2000
Same author

Role of female sex hormones in the development and reversal of dahl hypertension.

Hypertension (Dallas, Tex. : 1979)·2000
Same author

Gender differences in sympathetic nervous system regulation.

Clinical and experimental pharmacology & physiology·1999
Same author

Effect of sinoaortic deafferentation on renal wrap hypertension.

Hypertension (Dallas, Tex. : 1979)·1999
Same author

Role of the adrenal medullae in male and female DOCA-salt hypertensive rats.

Hypertension (Dallas, Tex. : 1979)·1998

Area of Science:

  • Endocrinology
  • Neuroscience
  • Pharmacology

Background:

  • The adrenal medulla is a key component of the peripheral sympathetic nervous system.
  • Endothelin (ET) is a peptide with known roles in cardiovascular regulation.
  • The presence and function of the ET system within the adrenal medulla are not fully elucidated.

Purpose of the Study:

  • To review the evidence for endothelin's influence on the peripheral sympathetic nervous system.
  • To examine the role of endothelin in regulating adrenal medulla function.
  • To explore the mechanisms by which endothelin affects catecholamine release.

Main Methods:

  • Review of existing literature on endothelin's effects on the adrenal medulla.
  • Analysis of studies identifying ET components (protein, mRNA, receptors, enzymes) in adrenal tissue.

Related Experiment Videos

  • Examination of functional studies measuring catecholamine release and adrenal blood flow.

    • Main Results:

    • An active endothelin system, including receptors (ETA and ETB), is present in the adrenal medulla.
    • Endothelin directly stimulates catecholamine release from chromaffin cells by increasing intracellular calcium.
    • Endothelin modulates adrenal blood flow and may influence adrenomedullary venous contraction, indirectly affecting catecholamine release.

    Conclusions:

    • Endothelin plays a significant role in regulating adrenal medulla function and peripheral sympathetic activity.
    • ET acts directly on chromaffin cells and indirectly via vascular effects to control catecholamine release.
    • Further research into the ET system in the adrenal medulla could reveal novel therapeutic targets.