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Transmission of primary nocturnal enuresis and attention deficit hyperactivity disorder

J N Bailey1, E M Ornitz, J G Gehricke

  • 1Neuropsychiatric Institute, University of California at Los Angeles, 90024, USA.

Acta Paediatrica (Oslo, Norway : 1992)
|January 8, 2000
PubMed

Insights

Primary nocturnal enuresis (PNE) and attention deficit hyperactivity disorder (ADHD) appear to be inherited independently in children. This study suggests no shared genetic factors link these common childhood conditions.

Area of Science:

  • Genetics
  • Pediatrics
  • Child Psychiatry

Background:

  • Primary nocturnal enuresis (PNE) is a common childhood disorder with a complex inheritance pattern.
  • Genetic factors are known to contribute to the familial occurrence of PNE.
  • PNE may exhibit genetic heterogeneity, potentially linked to comorbid conditions like attention deficit hyperactivity disorder (ADHD).

Purpose of the Study:

  • To investigate the potential co-occurrence of PNE and ADHD due to shared genetic factors.
  • To differentiate between genetic and non-genetic reasons for the co-occurrence of PNE and ADHD.
  • To examine the transmission patterns of PNE and ADHD within families.

Main Methods:

  • Utilized a family study approach.
  • Examined the inheritance of PNE in relatives of probands with and without ADHD.
  • Compared transmission patterns in PNE and control families, with and without ADHD.

Main Results:

  • The study observed independent transmission patterns for PNE and ADHD.
  • Findings indicate that PNE and ADHD do not appear to share common genetic susceptibilities.
  • The co-occurrence of these conditions is likely due to non-genetic factors.

Conclusions:

  • The inheritance of PNE and ADHD occurs independently.
  • There is no evidence of shared genetic etiology between PNE and ADHD based on this family study.
  • Future research should explore non-genetic factors contributing to the co-occurrence of these disorders.

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