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Studies on oral submucous fibrosis. III. Epithelial changes
Oral Surgery, Oral Medicine, and Oral Pathology
|February 1, 1976
Summary
Oral submucous fibrosis shows epithelial atrophy with hyperkeratosis and nuclear changes. Severe cases often lack glycogen, highlighting its potential as a precancerous oral lesion.
Area of Science:
- Oral pathology
- Oncology
- Dermatology
Background:
- Oral submucous fibrosis (OSMF) is a chronic, potentially malignant oral disorder.
- Epithelial changes are key indicators of OSMF progression and malignant transformation risk.
Purpose of the Study:
- To review literature on epithelial changes in OSMF.
- To present detailed findings from 38 OSMF biopsy specimens.
- To emphasize OSMF's precancerous potential.
Main Methods:
- Literature review on OSMF epithelial changes.
- Histopathological analysis of 38 OSMF biopsy specimens.
- Detailed examination of cellular and nuclear morphology.
Main Results:
- Observed epithelial atrophy with hyperkeratosis and pyknotic basal cell nuclei.
- Noted epithelial hyperplasia with hyperparakeratosis.
- Found absence of glycogen in most severe (Grade III) OSMF cases.
- Identified vacuolization, increased mitosis, and atypia in some cases.
Conclusions:
- OSMF exhibits diverse epithelial alterations.
- Glycogen absence in severe OSMF may indicate malignant potential.
- OSMF is a significant precancerous lesion requiring careful monitoring.