Related Experiment Video

Updated: Aug 6, 2026

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

Involvement of the humerus in two generations with spondyloepiphyseal dysplasia

U Givon1, S J Kumar, C I Scott

  • 1Department of Orthopaedics, Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA.

Clinical Orthopaedics and Related Research
|January 11, 2000
PubMed

Insights

Spondyloepiphyseal dysplasia can cause pseudarthrosis-like lesions in the humerus. These bone lesions in children with spondyloepiphyseal dysplasia congenita often remodel completely over time.

Area of Science:

  • Orthopedics
  • Genetics
  • Pediatrics

Background:

  • Spondyloepiphyseal dysplasia (SED) is a group of skeletal dysplasias characterized by disproportionate short stature and vertebral abnormalities.
  • Extraskeletal manifestations like retinal detachment and hearing loss are known complications.

Observation:

  • Two patients, a mother and her 6-year-old daughter, presented with pseudarthrosis-like lesions in the mid-diaphysis of both humeri.
  • The mother's lesions were asymptomatic and showed complete radiographic remodeling.
  • The child's lesions were also asymptomatic.

Findings:

  • Pseudarthrosis-like humeral lesions may represent an underrecognized manifestation of spondyloepiphyseal dysplasia congenita (SEDc).
  • These lesions demonstrate a natural history of complete bone remodeling over time.

Implications:

  • Radiographic examination of the humeri is recommended for all children diagnosed with SEDc.
  • Early identification of these humeral lesions can aid in understanding the full spectrum of SEDc manifestations.
  • Complete remodeling suggests a favorable prognosis for these specific bone lesions.

More Related Videos

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies06:53

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

Surgical Technique of the 3-Dimensional-printed Personalized Hip Implant for the Treatment of Canine Hip Dysplasia08:40

Surgical Technique of the 3-Dimensional-printed Personalized Hip Implant for the Treatment of Canine Hip Dysplasia

Published on: April 19, 2024

Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bones of the Upper Limb: Ulna01:15

Bones of the Upper Limb: Ulna

The ulna and radius are parallel bones of the antebrachium or the forearm. The ulna lies medially and consists of a bony tip called the olecranon process at its proximal end. This hook-like projection articulates with the olecranon fossa of the humerus and forms the "hinged" ulnohumeral part of the elbow joint. This joint facilitates forearm extension and flexion while preventing its hyperextension. Similarly, the coronoid process, another bony projection on the proximal/anterior side of the...
Bones of the Upper Limb: Radius01:09

Bones of the Upper Limb: Radius

The radius is longer of the two bones that make up the human antebrachium or forearm. At the proximal end, the radius articulates with the capitulum of the humerus and the radial notch of the ulna to form the elbow joint. At the distal end, the radius articulates with the ulna via the ulnar notch, forming the distal radioulnar joint. Distally, the radius also attaches to the carpal wrist bones (scaphoid and lunate) to form the radiocarpal joint.
The radius has a nail-shaped head, and a short...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...