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Published on: May 16, 2025
Leflunomide for the treatment of rheumatoid arthritis
N J Olsen1, V Strand, J M Kremer
1Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Abstract:
Leflunomide treatment appears to offer an alternative to methotrexate and sulfasalazine and is a welcome addition to the therapeutic armamentarium for treating active RA. Leflunomide treatment for more than 12 months results in clinically meaningful improvements in disease-specific measures of physical function. The phase 3 trials have shown leflunomide to be as effective as methotrexate and sulfasalazine and an option for initial DMARD therapy. As with all new agents, the long-term safety and value of leflunomide will be determined by use in the clinic.
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