Transient birth hypoxia increases behavioral responses to repeated stress in the adult rat

The aim of this study was to test if two birth complications, namely, transient global hypoxia during Caesarean section (C-section) birth or C-section birth per se, produce long-term changes in behavioral responses to repeated stress. Adult rats, that had been born vaginally, by C-section or by C-section with 10 min of global anoxia, were stressed for 8 days (15 min tail pinch daily) followed by challenge with the same stressor 2 weeks later. The main finding is that adult rats born by C-section + 10 min of anoxia showed enhanced locomotor activity on days 5 and 6 of the repeated stress period and at stress challenge 2 weeks later, compared to animals born vaginally or by C-section. It is concluded that transient global birth hypoxia can render the adult rat behaviorally hyper-responsive to repeated stress.