Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom.

O S Pedersen1, E B Pedersen

  • 1Department of Chemistry, University of Southern Denmark, Odense University.

Antiviral Chemistry & Chemotherapy
|January 11, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Borderline T-SPOT.TB results: test reliability, patient characteristics, and TB progression.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
Same author

HIV remains a deadly companion to drug-resistant TB in Ukraine.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2024
Same author

Prenatal exposure to airborne polychlorinated biphenyl congeners and male reproductive health.

Human reproduction (Oxford, England)·2022
Same author

A Comparison of Urine Dilution Ability between Adult Dominant Polycystic Kidney Disease, Other Chronic Kidney Diseases, and Healthy Control Subjects: A Case-Control Study.

International journal of nephrology·2020
Same author

Urine concentration ability is reduced to the same degree in adult dominant polycystic kidney disease compared with other chronic kidney diseases in the same CKD-stage and lower THAN in healthy control subjects - a CASE control study.

BMC nephrology·2020
Same author

Effect of 3% saline and furosemide on biomarkers of kidney injury and renal tubular function and GFR in healthy subjects - a randomized controlled trial.

BMC nephrology·2019
Same journal

The continuing need for therapeutic agents for respiratory syncytial virus infection.

Antiviral chemistry & chemotherapy·2023
Same journal

The development of BVDU: An odyssey.

Antiviral chemistry & chemotherapy·2023
Same journal

Active site polymerase inhibitor nucleotides (ASPINs): Potential agents for chronic HBV cure regimens.

Antiviral chemistry & chemotherapy·2022
Same journal

Reflections on the Rega Institute for Medical Research, at the fiftieth anniversary of the Rega Stichting vzw (Rega Instituut vzw, Rega Foundation).

Antiviral chemistry & chemotherapy·2022
Same journal

Meeting report: 34th international conference on antiviral research.

Antiviral chemistry & chemotherapy·2022
Same journal

Efficacy of oleandrin and PBI-05204 against bovine viruses of importance to commercial cattle health.

Antiviral chemistry & chemotherapy·2022
See all related articles

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are key HIV treatments. This review examines FDA-approved NNRTIs and new second-generation drugs designed to overcome drug resistance, improving HIV therapy.

Area of Science:

  • Virology
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are crucial in combination HIV therapy.
  • First-generation NNRTIs face challenges due to rapid development of drug resistance.
  • Effective HIV treatment requires overcoming resistance mechanisms.

Purpose of the Study:

  • To review the properties of FDA-approved non-nucleoside reverse transcriptase inhibitors.
  • To highlight recent advancements in developing second-generation NNRTIs.
  • To address the challenge of drug resistance in HIV treatment.

Main Methods:

  • Literature review of FDA-approved NNRTI drugs.
  • Analysis of recent research on second-generation NNRTI development.

Related Experiment Videos

  • Discussion of resistance mechanisms and strategies to overcome them.

    • Main Results:

    • First-generation NNRTIs are effective but prone to resistance.
    • Second-generation NNRTIs are being developed to combat resistance.
    • Understanding NNRTI properties is key to effective HIV management.

    Conclusions:

    • NNRTIs are vital components of HIV treatment regimens.
    • Overcoming NNRTI resistance is essential for long-term therapeutic success.
    • Ongoing research into novel NNRTIs promises improved HIV therapies.