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Macrolide resistance in group A streptococci.

D Savoia1, C Avanzini, K Bosio

  • 1Department of Clinical and Biological Sciences, University of Torino. Laboratory, Agnelli Hospital, Pinerolo (Torino) Laboratory, Paediatric Hospital, Torino, Italy. savoia@pasteur.sluigi.unito.it

The Journal of Antimicrobial Chemotherapy
|January 11, 2000
PubMed
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High rates of erythromycin resistance in Streptococcus pyogenes pharyngotonsillitis were observed in Italy. Genetic analysis revealed diverse genomic profiles, indicating resistance isn't due to a single clone or serotype.

Area of Science:

  • Microbiology
  • Genetics
  • Infectious Diseases

Background:

  • Streptococcus pyogenes causes pharyngotonsillitis in children.
  • Macrolide resistance in S. pyogenes is a growing public health concern.
  • Understanding resistance mechanisms is crucial for effective treatment.

Purpose of the Study:

  • To evaluate macrolide resistance phenotypes in S. pyogenes isolates from children with pharyngotonsillitis.
  • To investigate the genotypic characteristics of resistant strains.
  • To determine if resistance is linked to specific T serotypes or clonal spread.

Main Methods:

  • Phenotypic testing for macrolide resistance (erythromycin).
  • T protein typing and assays for opacity factor (OF) and protease production.

Related Experiment Videos

  • Pulsed-field gel electrophoresis (PFGE) for genomic profiling of resistant and susceptible strains.

    • Main Results:

    • High prevalence of erythromycin resistance (43.5-51.2%) observed in both study centers.
    • Three resistance phenotypes identified: constitutive (CR), inducible (IR), and a novel phenotype (NR).
    • PFGE revealed five distinct genomic profiles among resistant strains, with NR strains showing three patterns.

    Conclusions:

    • S. pyogenes strains exhibit significant genetic heterogeneity.
    • The high rate of erythromycin resistance is not attributed to the spread of a single clone.
    • Resistance phenotype is related to genomic patterns, with limited association with T serotype.