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Minimal persistent inflammation is also present in patients with seasonal allergic rhinitis
Background:
The allergic reaction is characterized by an inflammatory response, which is correlated to the allergen exposure, and is detectable in mite allergic patients, even when symptoms are absent.
Objective:
The study was aimed at assessing the presence of inflammation in patients with pollen allergy during a long observation period.
Methods:
Six patients, sensitized only to Betula alba, were enrolled. Evaluated parameters were (1) nasal symptoms, (2) inflammatory markers (ie, neutrophil and eosinophil number and intercellular adhesion molecule-1 expression on nasal epithelial cells), and (3) pollen count. Patients were examined during the pollen season every 4 days for 40 days and were observed 3 times after the pollen season.
Results:
A significant inflammatory reaction was evident throughout the pollen season, even during the days with a low pollen count and low or absent symptoms.
Conclusions:
The results of this study indicate that the global therapeutic strategy for allergic rhinitis should be revised and targeted to inflammatory phenomena rather than to symptoms alone.