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The preparation of amino-substituted biaryl libraries: the application of solid-supported reagents to streamline
1Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, Canada, M3J 1P3.
Biotechnology and Bioengineering
|January 12, 2000
Abstract:
A small library of isomeric benzylamino biaryls was generated in a semi-automated fashion using a solution-phase strategy employing a solid-supported, readily filterable base to facilitate electrophilic substitution followed in sequence by a metal-catalyzed cross-coupling reaction.