Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is dedifferentiated chondrosarcoma a 'de-differentiated' chondrosarcoma?

T Aigner, K K Unni

    The Journal of Pathology
    |January 12, 2000
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Simulated use of the water circuit disinfection device on a Mycobacterium chimaera-contaminated LivaNova 3T Heater Cooler Device: results of mycobacterial and bacterial surveillance.

    The Journal of hospital infection·2025
    Same author

    PEDF Is Associated with the Termination of Chondrocyte Phenotype and Catabolism of Cartilage Tissue.

    BioMed research international·2017
    Same author

    3D ultrasound biomicroscopy for assessment of cartilage repair tissue: volumetric characterisation and correlation to established classification systems.

    European cells & materials·2016
    Same author

    Chondroblastoma.

    Orthopedics·2014
    Same author

    Mayo clinic tumor rounds.

    Orthopedics·2014
    Same author

    Malignant lymphoma of bone.

    Orthopedics·2014
    Same journal

    Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights.

    The Journal of pathology·2026
    Same journal

    Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis.

    The Journal of pathology·2026
    Same journal

    Optical mapping reveals a higher level of large-scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease.

    The Journal of pathology·2026
    Same journal

    FTO-mediated m6A modification of protein disulfide-isomerase activates VEGFA-VEGFR2 to suppress programmed cell death in osteosarcoma.

    The Journal of pathology·2026
    Same journal

    Dopamine inhibits retinal pathological neovascularization in the oxygen-induced retinopathy mouse model.

    The Journal of pathology·2026
    Same journal

    Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer.

    The Journal of pathology·2026
    See all related articles

    Dedifferentiated chondrosarcoma, a model for sarcoma evolution, originates from a single clone. Two subtypes exist, differing in when their distinct tumor components arise during development.

    Area of Science:

    • Oncology
    • Cancer Biology
    • Pathology

    Background:

    • Dedifferentiated chondrosarcoma serves as a key model for understanding the dedifferentiation process in sarcomas.
    • These tumors present two distinct mesenchymal differentiation components, raising questions about their origin and development.

    Discussion:

    • Current research supports a common monoclonal origin for both tumor components in dedifferentiated chondrososarcoma.
    • This suggests that dedifferentiated chondrosarcoma exemplifies mesenchymal transdifferentiation in vivo.

    Key Insights:

    • Dedifferentiated chondrosarcomas arise from a single clone, with distinct tumor portions originating from a common ancestor.
    • Two distinct categories of dedifferentiated chondrosarcoma are identified based on their cell biology and the timing of tumor component divergence.

    Related Experiment Videos

    Outlook:

    • Further research will clarify the precise mechanisms and timing of tumor splitting in dedifferentiated chondrosarcoma.
    • Understanding these processes may lead to novel therapeutic strategies for this aggressive cancer.