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Expression of Fas ligand in newly diagnosed childhood acute lymphoblastic leukemia
1German Cancer Research Center, Department of Oncological Diagnostics and Therapy, Heidelberg, Germany.
Abstract:
Immunocytochemistry was used to analyze the expression of the Fas ligand (FasL) in sixty-four children with newly diagnosed acute lymphoblastic leukemia (ALL). FasL expression was detected in 55 of 64 children (86%). Children with newly diagnosed ALL and FasL expression exhibited longer relapse-free and overall survival times under chemotherapy than did patients who did not express the Fas ligand. These data suggest that Fas/FasL mediated signaling may play a general role in the cytotoxicity of anticancer drugs.
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