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Updated: Aug 19, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 3, 2015
[Radiobiological assessment of radiation injuries in various regimens of total body irradiation]
B P Afanas'ev1, A P Kozlov, A A Akimov
1N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Abstract:
A radiobiological evaluation of dose-time regimens of total body irradiation (TBI) using a single-exposure multi-target (MM) and a linear-quadratic (LQM) models of cell destruction has been carried out. An equivalent of single dose of acute irradiation was used as a criterion of biological effect of LQM. The latter proved useful in analyzing all kinds of dose-time regimens of TBI including those employing different doses. Practically speaking, single exposure to 5 Gy and irradiation by three daily fractions in a total dose of 10 Gy may be recommended for wide clinical application.

