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[The comparative activity of cefepime and other current antibiotics against microorganisms isolated from patients in

V A Kurchavov1, N V Beloborodova, A V Biriukov

  • 1Laboratory of Microbiology, N. F. Filatov Municipal Pediatric Clinical Hospital No. 13, Moscow.

Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
|January 12, 2000
PubMed

Insights

Cefepime demonstrated high susceptibility (92%) against pediatric intensive care unit isolates. This antibiotic showed effectiveness between third-generation cephalosporins and carbapenems, offering a valuable treatment option.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Antibiotic resistance in pediatric intensive care units (PICUs) poses a significant challenge.
  • Evaluating the efficacy of various antibiotics is crucial for effective treatment strategies.

Purpose of the Study:

  • To compare the in vitro activity of cefepime, ceftazidime, ceftriaxone, ciprofloxacin, imipenem, and piperacillin/tazobactam.
  • To assess antibiotic susceptibility patterns of bacterial isolates from PICU patients.

Main Methods:

  • Collected 100 bacterial isolates from PICU patients between October and December 1998.
  • Identified isolates using the Walkaway-40 System.
  • Determined antibiotic susceptibility via E-test on Mueller-Hinton II agar, interpreted per NCCLS guidelines.

Main Results:

  • Cefepime exhibited 92% susceptibility among isolates.
  • Third-generation cephalosporins showed 70-75% susceptibility.
  • Piperacillin/tazobactam demonstrated high susceptibility with only 7% combined resistant/moderately resistant isolates.
  • Cefepime's activity was found to be between third-generation cephalosporins and carbapenems.

Conclusions:

  • Cefepime is a highly effective antibiotic against common PICU bacterial pathogens.
  • Piperacillin/tazobactam also shows significant efficacy.
  • These findings support the use of cefepime and piperacillin/tazobactam in managing infections in pediatric intensive care settings.

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