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New triterpenoids with antibacterial activity from Zizyphus joazeiro
W Schühly1, J Heilmann, I Calis
1Department of Pharmacy, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland.
Planta Medica
|January 12, 2000
Abstract:
The stem bark of the Brazilian medicinal plant Zizyphus joazeiro C. Mart. was phytochemically investigated. Three known compounds (betulinic, ursolic and alphitolic acid) and three new derivatives of betulinic acid, 7 beta-(4-hydroxybenzoyloxy)-betulinic acid, 7 beta-(4-hydroxy-3'-methoxybenzoyloxy)-betulinic acid and 27-(4-hydroxy-3'-methoxybenzoyloxy)-betulinic acid which showed a considerable activity against Gram-positive bacteria were isolated from the dichloromethane extract. The structures were established on the basis of NMR spectroscopy and mass spectrometry.