Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Vaginally applied diquat intoxication.

J Rudez¹, K Sepcić, J Sepcić

¹University of Rijeka, Croatia.

Journal of Toxicology. Clinical Toxicology

|January 12, 2000

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The sensing of membrane microdomains based on pore-forming toxins.

Current medicinal chemistry·2012

Same author

CTLA-4 +49 A/G gene polymorphism in Croatian and Slovenian multiple sclerosis patients.

International journal of immunogenetics·2011

Same author

Sildenafil induced choreoathetosis in men with Parkinson's disease.

International journal of clinical pharmacology and therapeutics·2009

Same author

Biological Activity of Some Magnesium(II) Complexes of Quinolones.

Metal-based drugs·2008

Same author

Woodhouse-Sakati syndrome: case report and symptoms review.

Genetic counseling (Geneva, Switzerland)·2007

Same author

Angiotensin-converting enzyme I/D gene polymorphism and risk of multiple sclerosis.

Acta neurologica Scandinavica·2006

Same journal

Ingestion of high-dose buprenorphine by a 4 year-old child.

Journal of toxicology. Clinical toxicology·2005

Same journal

A reassessment of topical organic phosphorus insecticide exposures and permanent paralysis.

Journal of toxicology. Clinical toxicology·2005

Same journal

Methamphetamine toxicity secondary to intravaginal body stuffing.

Journal of toxicology. Clinical toxicology·2005

Same journal

Duodenal perforation after ibuprofen overdose.

Journal of toxicology. Clinical toxicology·2005

Same journal

Delayed dystonia following pimozide overdose in a child.

Journal of toxicology. Clinical toxicology·2005

Same journal

Pattern of acute poisonings in Mashhad, Iran 1993-2000.

Journal of toxicology. Clinical toxicology·2005

See all related articles

A woman experienced severe symptoms including acute renal failure and neurological deficits after intravaginal diquat concentrate exposure. Prompt hemodialysis and supportive care were crucial for her recovery from this toxic herbicide exposure.

Area of Science:

Toxicology
Clinical Case Reports
Neurology

Background:

Diquat is a widely used herbicide with known toxicity.
Accidental or intentional ingestion can lead to severe systemic effects.
Vaginal exposure to concentrated herbicides is rare.

Observation:

A patient presented with corrosive vulvovaginitis and systemic symptoms after intravaginal diquat concentrate introduction.
Initial symptoms included abdominal pain, vomiting, diarrhea, chest pain, and somnolence.
Acute renal failure developed on day 3, requiring hemodialysis.

Findings:

The patient exhibited neurological deficits, including dysarthria and spastic tetraparesis, persisting for 3 months.
Electroencephalogram showed initial diffuse slowing, normalizing by day 28.

Related Experiment Videos

Peripheral nerve biopsy revealed no demyelination or axonal damage, suggesting a central or functional neurological impact.

Implications:

This case highlights the severe systemic toxicity of diquat, even via non-traditional exposure routes.
It underscores the importance of recognizing diquat poisoning symptoms and managing acute renal failure.
The neurological sequelae and their resolution provide insights into the neurotoxic effects of diquat poisoning.