Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prospects for fetal gene therapy.

E Y Yang1, A W Flake, N S Adzick

  • 1Department of Surgery, the Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, PA 19104, USA.

Seminars in Perinatology
|January 12, 2000
PubMed
Summary

Prenatal gene therapy offers a promising approach for treating fatal genetic diseases before birth. The fetal environment may provide unique advantages for this novel therapeutic strategy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased neonatal morbidity in 'stomach-down' left congenital diaphragmatic hernia: implications of prenatal ultrasound diagnosis for counseling and postnatal management.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2021
Same author

Reply.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2020
Same author

Fetal Intraventricular Hemorrhage in Open Neural Tube Defects: Prenatal Imaging Evaluation and Perinatal Outcomes.

AJNR. American journal of neuroradiology·2020
Same author

Myelomeningocele sac associated with worse lower-extremity neurological sequelae: evidence for prenatal neural stretch injury?

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019
Same author

Learning curves of open and endoscopic fetal spina bifida closure: systematic review and meta-analysis.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019
Same author

Fetal echocardiographic assessment of cardiovascular impact of prolonged support on EXTrauterine Environment for Neonatal Development (EXTEND) system.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019

Area of Science:

  • Genetics
  • Molecular Biology
  • Developmental Biology

Background:

  • Advances in prenatal diagnosis and gene transfer technologies.
  • Potential for treating genetic diseases that are fatal prenatally or perinatally.

Purpose of the Study:

  • To explore the potential of prenatal gene therapy as a treatment strategy.
  • To evaluate the advantages of the fetal environment for gene therapy.

Main Methods:

  • Review of current gene transfer technologies.
  • Analysis of biological advantages of the fetal environment.
  • Consideration of safety and efficacy for clinical application.

Main Results:

  • Prenatal gene therapy is a viable consideration due to technological advances.
  • The fetal environment may offer unique biological benefits for gene therapy.
  • Safety and efficacy are critical factors for future clinical use.

Conclusions:

  • Prenatal gene therapy represents a potential new molecular therapeutic approach.
  • This strategy could significantly impact prenatal intervention for genetic disorders.
  • Further research is needed to resolve safety and efficacy before clinical application.

Related Experiment Videos