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Ozone carcinogenesis revisited.

H Witschi1, I Espiritu, K E Pinkerton

  • 1Institute of Toxicology and Environmental Health, Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA. hrwitschi@ucdavis.edu

Toxicological Sciences : an Official Journal of the Society of Toxicology
|January 12, 2000
PubMed
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This study found that ozone exposure did not cause lung cancer in mice. Strain A/J mice showed resistance to chronic ozone toxicity, with no significant increase in lung tumors observed.

Area of Science:

  • Environmental Health
  • Toxicology
  • Carcinogenesis

Background:

  • Ozone is a known respiratory irritant.
  • The carcinogenic potential of ozone in the lungs remains a concern.
  • Strain A/J mice are commonly used in lung cancer research.

Purpose of the Study:

  • To investigate whether ozone acts as a lung carcinogen in female strain A/J mice.
  • To determine the dose-response relationship, if any, between ozone exposure and lung tumor development.
  • To assess the long-term effects of ozone exposure and subsequent filtered air recovery on lung health.

Main Methods:

  • Female strain A/J mice were exposed to varying concentrations of ozone (0.12, 0.5, 1.0 ppm) or filtered air for 6 hours/day, 5 days/week.
  • Animals were analyzed after 5 months, with remaining groups either continuing ozone exposure or being moved to filtered air for an additional 4 months.

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  • Lung tumor multiplicity and incidence were assessed, alongside morphometric analysis of centriacinar lesions.

    • Main Results:

    • No ozone-related deaths occurred during the study.
    • No significant increase in lung tumor multiplicity or incidence was observed in ozone-exposed mice compared to controls.
    • A small, statistically insignificant increase in centriacinar lesions was noted at the highest ozone concentration (1.0 ppm).

    Conclusions:

    • Ozone is not a lung carcinogen in strain A/J mice at the tested exposure levels.
    • Strain A/J mice exhibit notable resistance to chronic ozone toxicity.
    • Further research may be needed to explore ozone's effects in other mouse strains or at higher concentrations.