Related Experiment Video
Updated: Aug 12, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
Published on: March 20, 2018
Beta-carotene generates thiobarbituric acid-reactive substances by interaction with nitrogen dioxide in air
K Kikugawa1, K Hiramoto, A Hirama
1School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan. kikugawa@ps.toyaku.ac.jp
Abstract:
Generation of thiobarbituric acid-reactive substances (TBARS) from methyl linoleate in the exposure of nitrogen dioxide/air was inhibited by beta-carotene in a dose-dependent manner. However, introduction of nitrogen dioxide/air or oxygen into a solution of beta-carotene generated a significant amount of TBARS accompanying loss of its characteristic yellow color. Storing beta-carotene in a solid state at ambient temperatures in air generated a large amount of TBARS accompanying loss of its yellow color. TBARS from beta-carotene may interfere the measurement of TBARS from polyunsaturated fatty acids, and may give undesirable effects on biomaterials.
More Related Videos
Related Concept Videos
Preparation and Reactions of Thiols
Oxidations of Aldehydes and Ketones to Carboxylic Acids
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
Loss of Carboxy Group as CO2: Decarboxylation of β-Ketoacids
2° Amines to N-Nitrosamines: Reaction with NaNO2
Radical Autoxidation
Reactions of Carboxylic Acids: Introduction

