Related Experiment Video

Updated: Oct 18, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
11:55

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

Blockade of costimulatory pathways of T-cell activation: the solution to acute and chronic rejection?

C van Kooten1

  • 1Department of Nephrology, Leiden University Medical Center, The Netherlands. Kooten@mail.Medfac.LeidenUniv.nl

Current Opinion in Nephrology and Hypertension
|January 12, 2000
PubMed

Understanding of how antigen-specific signals and costimulatory molecules are involved in T-cell activation has resulted in new strategies to interfere with allograft rejection. The present review focuses on the role of two receptor-ligand pairs: CD28 and cytotoxic T lymphocyte associated antigen-4, which interact with the B7 ligands (CD80, CD86); and CD40, which interacts with the CD40L (CD154). On the basis of the extensive tissue distribution of CD40, it is likely that the CD40/CD40L system plays a much broader role.

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