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Palatal growth and chemotherapy: effects of cyclophosphamide on bone formation in the intermaxillary suture in
M Näsman1, C M Forsberg, S Lindskog
1Department of Orthodontics, School of Dentistry, Karolinska Institutet, Huddinge, Sweden.
Objective:
To study the effect of cyclophosphamide (Cy) on bone formation in the maxillary median suture of young rats.
Study Design:
Doses of 30 mg/kg body weight of Cy were administered to 12 experimental rats at 10 and 13 days of age. A corresponding amount of 0.9% sodium chloride was given to 6 control rats at the same ages. At 31 days, the median maxillary suture was studied histologically in the experimental and control rats.
Results:
Structural changes of the osteogenic layers and cartilage components of the suture could be seen in the experimental rats. The thickness of the palatal bone was only 66% of that of the control rats, and the experimental rats also exhibited significantly reduced width of the suture.
Conclusion:
This study shows that Cy by itself can cause disturbances in bone formation in rats.