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Hyperuricemia in severe pulmonary hypertension
M A Voelkel1, K M Wynne, D B Badesch
1Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver, CO, USA.
Chest
|January 13, 2000
Summary
High uric acid (UA) levels correlate with elevated right atrial pressure (RAP) in patients with primary pulmonary hypertension (PPH). Some PPH patients show reduced UA levels during prostacyclin treatment.
Area of Science:
- Cardiology
- Pulmonology
- Nephrology
Background:
- Hyperuricemia is common in myeloproliferative and lymphoproliferative disorders.
- The prevalence of hyperuricemia in severe pulmonary hypertension is unknown.
Purpose of the Study:
- To investigate the relationship between serum uric acid levels and severe pulmonary hypertension.
- To determine if hyperuricemia is common in patients with severe pulmonary hypertension.
Main Methods:
- Evaluated 442 consecutive patients with right heart catheterization.
- Measured serum uric acid (UA) in 191 patients.
- Analyzed correlation between natural logarithm of serum UA (lnUA) and mean right atrial pressure (RAP).
Main Results:
- A positive correlation was found between lnUA and RAP in the entire cohort (n=191).
- The correlation was stronger in patients with primary pulmonary hypertension (PPH) (r=0.642, p<0.001).
- Serum UA decreased in 61% of PPH patients during prostacyclin infusion therapy.
Conclusions:
- Elevated right atrial pressure in PPH is positively correlated with serum uric acid levels.
- Chronic prostacyclin infusion therapy can decrease serum UA in some PPH patients.