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The hereditary spastic paraplegias
1Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke's Hospital, UK. ereid@hgmp.mrc.ac.uk
Journal of Neurology
|January 13, 2000
Abstract:
The hereditary spastic paraplegias are a complex group of neurodegenerative conditions which are characterised by slowly progressive lower limb spasticity. This article describes the main clinical features of pure and complicated hereditary spastic paraplegias and summarises recent advances in our understanding of the molecular genetics of these conditions.