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Related Experiment Videos

Multiple emulsions containing rifampicin.

A J Khopade1, N K Jain

  • 1Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar, India.

Die Pharmazie
|January 13, 2000
PubMed
Summary

Stable multiple emulsions containing rifampicin were developed for improved tuberculosis therapy. These formulations demonstrated good stability and prolonged plasma drug levels in vivo.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Emulsion Technology

Background:

  • Tuberculosis (TB) remains a significant global health challenge requiring effective drug delivery systems.
  • Rifampicin is a cornerstone anti-TB drug, but its efficacy can be limited by pharmacokinetic challenges.
  • Developing stable and effective oral formulations is crucial for enhancing TB treatment outcomes.

Purpose of the Study:

  • To formulate and optimize stable multiple emulsions encapsulating rifampicin.
  • To characterize the drug release kinetics and physical stability of the developed emulsions.
  • To evaluate the in vivo performance of the rifampicin-loaded multiple emulsions for improved tuberculosis therapy.

Main Methods:

  • Multiple emulsions were prepared using additives in aqueous and oily phases, optimizing formulation and process variables.
  • Drug release studies were conducted, fitting data to the Higuchi equation to determine diffusion coefficients.
  • Stability was assessed over three months, evaluating physical parameters and drug leakage.
  • In vivo studies in human volunteers measured plasma rifampicin levels after oral administration.

Main Results:

  • Optimized multiple emulsions exhibited good physical stability, with no significant creaming, phase separation, or viscosity changes.
  • Drug release followed Higuchi kinetics, and effective diffusion coefficients were calculated.
  • Stability studies confirmed minimal drug leakage and stable droplet size upon storage and stress.
  • Oral administration in human volunteers resulted in prolonged plasma rifampicin concentrations.

Conclusions:

  • Stable multiple emulsions encapsulating rifampicin were successfully developed.
  • The optimized formulation demonstrated favorable drug release, stability, and in vivo pharmacokinetic profiles.
  • These rifampicin-loaded multiple emulsions show significant potential for an improved tuberculosis therapy.

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