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Updated: Oct 18, 2026

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes
Published on: September 13, 2022
Evaluation of the role of mitotic instability in karyotypically normal men with oligozoospermia
M R Gazvani1, E D Wilson, D H Richmond
1Department of Obstetrics and Gynaecology, Liverpool Women's Hospital, United Kingdom.
Objective:
To estimate the incidence of sex chromosome aneuploidies in the somatic cells of karyotypically normal infertile men and fertile donors.
Design:
A prospective, two-phase, controlled study.
Setting:
Reproductive medicine and medical genetics units of a teaching hospital.
Patient(S):
Ten patients with oligozoospermia and 10 sperm donors with proved fertility, all with a normal karyotype 46 XY.
Intervention(S):
Multicolor fluorescence in situ hybridization (FISH) of peripheral blood lymphocytes using a probe cocktail containing the alpha satellites DXZ1 for the X centromere and DYZ1 for the heterochromatic region of the long arm of the Y and the radiolabeled alpha satellite D18Z1 for chromosome 18.
Main Outcome Measure(S):
The incidence of sex chromosome aneuploidies in both groups.
Result(S):
A 13-fold increase in sex chromosome aneuploidies was observed in the somatic cells of infertile men with "unexplained" oligozoospermia compared to donors (P=.008).
Conclusion(S):
These findings provide suggestive evidence for the existence of an inherent mitotic instability in men with unexplained oligozoospermia.
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