Related Experiment Video
Updated: Aug 11, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Evaluation of resorbable barriers for preventing surgical adhesions
P B Arnold1, C W Green, P A Foresman
1Department of Plastic Surgery, University of Virginia Health System, Charlottesville 22908, USA.
Objective:
To evaluate the ability of collagen film, collagen gel, sodium hyaluronate/carboxymethylcellulose film, and fibrin glue to prevent adhesion formation.
Design:
Randomized trial using a rat model of a standardized abdominal wound and cecal wound.
Setting:
University research laboratory.
Animal(S):
Sprague-Dawley female rats.
Intervention(S):
Resorbable barriers or no barrier (controls) were placed between an abdominal wall wound (1 cm x 2 cm) and a similarly sized cecal wound.
Main Outcome Measure(S):
Adhesion formation between wounds was assessed and quantitated 7 days after surgery.
Result(S):
Without treatment, 34 of 35 untreated rats (97%) developed adhesions. Treatment with collagen gel (3 of 33 rats), collagen film (3 of 10 rats), or sodium hyaluronate/carboxymethylcellulose film (2 of 10 rats) significantly reduced the incidence of adhesion formation. Treatment with fibrin sealant resulted in 9 of 10 animals having adherent wounds 7 days after surgery.
Conclusion(S):
Resorbable barriers of collagen gel, collagen films and sodium hyaluronate/carboxymethylcellulose film were effective in significantly reducing adhesion formation. Fibrin sealant at 7 days had an incidence of adhesion formation similar to that in untreated control animals.
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